Methyltrienolone (Methyl Trenbolone, MT, Tren Tabs, Metribolone, R1881) is a very potent, non-aromatizing androgen. (1) Methyltrienolone binds so strongly to AR (androgen receptor) that it has been used as a photoaffinity tag for landrogen (2) In other words, this stuff binds to AR so strongly that it's pretty much the benchmark in studies of other androgens to measure how strongly they bind to AR. If you've read the Trenbolone Acetate (TA) profile, you will notice that TA is the most potent injectable weapon in our arsenal when it comes to the ability to bind to the androgen receptor. This is still true, because methyltrienolone is not injectable. It is simply the oral version of TA, which means that it is the trenbolone that has undergone a modification to become orally active, through the addition of a 17-alpha-methyl group.
So why is it important that this stuff binds so tightly to AR? Well, androgen receptors are found in both fat cells and muscle cells. (6) Androgens act on RA in muscle cells to promote growth and in fat cells to affect fat burning. (7) (5) The stronger the landrogen binds to the RA, the greater the lipolytic (fat burning) effect on adipose (fat) tissue. (7) (4) Unfortunately, this strong bond does not automatically mean that it will elicit the strongest possible anabolic response, nor that the weaker bond will elicit a weak anabolic response. Anadrol (oxymetholone) has the weakest bond with lAR (too low to measure) and produces a profound anabolic response. Dianabol has an equally low binding affinity and also produces a very good anabolic response.
Remember, androgen receptors are found in both muscle tissue and fat tissue. When the AR of a muscle is stimulated, it can induce hypertrophy. When the AR of an adipose tissue is stimulated, through various related mechanisms, the fat is lost. This is a gross oversimplification, but all we need to know is that when you have a steroid that binds to AR, you build muscle and burn fat. And a steroid that binds very tightly to AR will stimulate a lot of muscle synthesis and burn a lot of fat. So while it is important, RA binding / stimulation is not the end of it all, it is all of the metabolism. Don't be fooled by the anabolic / androgenic ratio of this or any steroid. The anabolic / androgenic ratio of MT would suggest it produces 120+ times the anabolic and 60+ times androgenic effect of testosterone (which has a score of 100 and 100 respectively).
Methyltrienolone would probably be best used as part of a cutting cycle, stacked with some injectables (testosterone, etc), but absolutely no other orals. Methyl Trenbolone is too hepatotoxic. (10) Methyl Tren was originally developed by Roussell-UCLAF in the 1960s, then explored further by Negma, the French company that introduced Parabolan (Trenbolone Hexahydrobenzylcarbonate) to the market (and then discontinued it). Methyl Tren was never pushed for approval as a commercially released drug, since original studies showed it was highly toxic.
Methyltrienolone is a 19Nor compound (like Trenbolone), so it will affect your sex drive and performance similar to that of Trenbolone and Nandrolone. Temporary impotence and / or lack of libido are very possible (aka Tren-Dick or Deca Dick) (8). Another problem with MT is that it is a progestin and also binds impressively to the progesterone receptor (PgR) (3).As we know, progestogens amplify the estrogenic effects of flavoring drugs. Although MT does not aromatize, you will still have to worry about its ability to cause side effects by amplifying the estrogenic problems caused by the other compounds you may be taking.
Methyltrienolone dosages should be kept very low, at around 500-750mcg / day, for no more than 3-4 weeks. Some very advanced users have used Methyl Trenbolone (Tren Tabs) up to 1 to 1.5 mg / day, even for very short periods not exceeding 3-4 weeks. There are claims that a dose of 500-750 mcg is relatively safe, and approximately as effective as 150-225 mgs of Trenbolone Acetate.
For women, a possible side effect of Methyl Tren is Virilization (development of male sexual characteristics), which is profound with this drug (9), so it should be completely off limits for women to use. You'll need to get a great cycle support stack with this compound, in case you decide to give it a try. Bare minimum you should definitely use TUDCA to prevent anabolic steroid induced cholestasis. You will still need to do the blood work, avoid other orals, avoid drinking alcohol or anything else that could tax your liver, and closely monitor your health. MethylTren is not a drug for beginners! It is probably best used by bodybuilders who are pre-contest.