Azab 100 Azithromycin

Description

Description

Azab 100 (Azithromycin) is a semi-synthetic antibiotic, the first of a subclass of azalides slightly different in structure from classical macrolides.

Obtained by modifying 14-membered macrolides by including the nitrogen atom in the lactone ring between 9 and 10 carbon atoms, in which the ring transforms into a 15-membered member. This restructuring leads to a significant increase in the acid resistance of the drug up to 300 times compared to erythromycin.

Action of Azithromycin

Broad spectrum antibacterial azalide, bacteriostatic. Communicating with the 50S-ribosomal subunit, it inhibits peptidtranslokazu in the translation stage, inhibits protein synthesis, inhibits the growth and reproduction of bacteria, in high concentrations it has a bactericidal effect. It acts on extracellular and intracellular pathogens.

indications

Upper respiratory tract and upper respiratory tract infections caused by susceptible pathogens: pharyngitis, tonsillitis, laryngitis, sinusitis, otitis media, scarlet fever, lower respiratory tract infections: pulmonary bronchitis (including atypical, chronic exacerbation), skin and tissue infections soft: erysipelas, impetigo, secondarily infected dermatoses, urinary tract infections caused by Chlamidia trachomatis: gonorrheal and negonoreyny urethritis, cervicitis, Lyme disease (early stage), peptic ulcer and 12 duodenal ulcer associated with Helicobacter pylori (in a combination therapy) .

Azithromycin side effects

Hypersensitivity (including macrolide), hepatic and / or renal insufficiency.

From the digestive system: ingestion diarrhea (5%), nausea (3%), abdominal pain (3%), 1% or less flatulence, vomiting, melaena, cholestatic jaundice, elevated hepatic transaminase, In addition, constipation in children, decreased appetite, gastritis, candidiasis of the oral mucosa.

From the CCC: palpitations, chest pain (1% or less).

From the nervous system: dizziness, headache, drowsiness, sensorineural deafness, tinnitus, headache in children (in the treatment of otitis media), hyperkinesis, anxiety, neurosis, sleep disturbances (1% or less).

From the urogenital system: vaginal candidiasis, nephritis (1% or less).

Allergic reactions: rash, urticaria, itching, angioneurotic edema, at / in bronchospasm introduction (1% or less).

Local reactions: at / in the introduction pain and inflammation at the injection site.

Other: asthenia, photosensitivity, conjunctivitis in children, change in flavor (1% or less).